Neurodegenerative diseases and the Microbiome
Parkinson's disease
Parkinson's Disease, cause in the brain or gut?
"All diseases start in the gut" - Hippocrates
The microbiota and microbiome has been a really hot research topic the last decade. Recent research shows that gut-brain interactions might be influenced by someone's microbiota conditions. Besides, recent studies show that the gut-brain axis, including the autonomic and enteric nervous system, and the microbiota might be affected in Parkinson's disease (PD) [1].
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Parkinson's disease and the microbiome
Changes in the microbiota of the gut may cause problems which not only lead to alterations in the gastrointestinal trackt and the immune system, it also influences the enteric nervous system (ENS) as well as neurons and glial cells. In patients with Parkinson's Disease (PD) is the microbiome in the colon disturbed which could lead to dysbiosis. This might be the mechanism causing misfolding in alpha-synuclein, which is an important protein in the pathogenesis of PD, and could therefore contribute to the pathology in PD.
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Multiple Sclerosis
A role for the microbiome in Multiple Sclerosis?
The gut microbiome is essential for a healthy life. A
dysbiosis in these gut bacteria is found in MS patients, and this may play an
important role in the pathogenesis of the disease. In this article you can find
some general information and a review of a meta-analysis on this subject.
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Fecal microbiota transplantation in MS
A disbalance in the gut microbiome of MS patients is
thought to be an important factor in the pathogenesis of the disease. Modifying
the microbiome in these patients would be an option for novel treatment of MS.
In this article the possibility of fecal microbiota transplantation is
described, illustrated with a case-report.
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